Philosophical trends such as the philosophy of religion, especially Thomism, existentialism, and phenomenology emerged in Lithuanian philosophy during the 20th century. The article discusses the chief preconditions of the spread of existentialism, in particular the dominant Christian existentialism, in Lithuania and its influence on Lithuanian culture. The best known representatives of this philosophical trend were J. Girnius and A. Maceina. There are two periods of existentialism and its development in Lithuania: the first one includes the independence years and the second covers the time of the Soviet occupation. The author discusses its influence on Lithuanian literature and introduces the main problems of existential philosophy.