The debate between Einstein, Bohr, Fock and others on the issues of continuity vs. discontinuity and determinism vs. indeterminism finds an epistemological solution in the principle of conjugation based on the concepts of structural relativity (1946) and of irreversibility of temporal action (1948). The acts of absorption and emission of a quantum, making up the structure of the Universe are objective in nature. Nevertheless, the structure of the global reality can never be represented in its innumerable process varieties as a unique explicative system and can be adequately tested through the conjugate and alternative use of four distinct paradigmatical classes of systems: deterministic, probabilistic, indeterministic and informational.