Neurological disease both results from and produces imbalances in the functions of brain circuitry, with resultant alterations in behavior, cognition, and social interactions, among others aspects. These issues can contribute heightened risk for suicidal behavior under a diathesis consistent with such behavior. In this chapter, risk for suicide is addressed for a number of neurological disorders, including Autism Spectrum Disorder (ASD), Parkinson's Disease, epilepsy, and Tourette's Disorder. Neurologic disease is very frequently comorbid with psychiatric disease, although it can be difficult to separate symptoms of the primary neurological disorder from what might be an independent psychiatric disorder. However, given the high incidence of psychiatric symptoms in neurological disorders, especially anxiety and depression, some of these patient populations can be at especially high risk, and should be carefully monitored as a result.