On the basis of the assumption that amputation stump pain during or after the development of a neuroma is evoked by peripheral nerve impulses originating at the neuroma itself, the first efforts in surgical and nonsurgical therapy are directed at a dissection or a blockade of these peripheral impulses. As far as the dissection is concerned in cases of circumscribed pain of the amputation stump, resection of the neuroma was already recommended in the last century. In fact, recurrence of both the neuroma and the pain occurred in nearly all cases. Later, other methods were proposed in order to prevent a recurrence of neuroma; namely endoneural injection with alcohol and various chemical substances proximal to the resection area and electrocoagulation. Mechanical procedures were also performed, such as fitting a metal clip around the central stump of the nerve or closing the epineurium after resection of a neuroma to avert an uncontrolled sprouting of nerve fibers [3, 4]. Experience, however, again showed that all these different kinds of treatment failed to achieve lasting and reliable pain relief [1].