This chapter concerns the philosophy of Friedrich Nietzsche, in particular, a consideration of Nietzsche as a metaphysical thinker. This chapter is divided into three main sections: (1) a discussion of Nietzsche's philosophy of science vis-à-vis his atheism, (2) a discussion of Nietzsche's metaphysics through the lens of Martin Heidegger; and (3) a discussion of Nietzsche's overcoming of metaphysics in the context of art. The goal of this chapter is to establish Nietzsche's thinking on the materialist side of the Gigantomachy.