In this chapter, we examine the science policy of systems biology and perspectives thereof. Based on interviews with actors from different fields such as science, politics, media, and economy, we contrast the scientists' conceptualization and assessment of systems biology and their perception of science policy with that of societal actors on what systems biology is and how it should be governed.Discussions in these different fields are interconnected. We therefore highlight interdependences and shared topics where the separate discourses influence and interact with each other. Aspects addressed touch upon the identity of systems biology as a new science, and the effect of further specialization, the similarity of the scientific and public images of what systems biology is, and the sustainability of funding. While participation and inclusion of the general public is seen as an important achievement in politics, media, and public interest groups, it is less important in the scientific perspective. This raises the question of whether it is ascribed an appropriate role.