Without going again into general considerations, we now try to present our view of scientific hypotheses as intermediary hypotheses — intermediary between general facts and metaphysics frameworks: the scientific hypotheses ideally explain general facts and conform to adopted metaphysics. And they should be empirically testable. For example, Newtonian hypotheses should all conform to Newton's framework of forces acting at a distance within Euclidean space along a universal time scale; and they should explain all the known general facts of the physical world. The frameworks in medicine are, as we repeatedly say, generalist holism and externalist mechanism. The trouble with scientific medicine, we contend, is in the paucity of its explanatory hypotheses — regardless of their conforming or not conforming to either frame.