Headache workup and treatment are generally managed as an outpatient. Occasionally, however, the severity of pain can become so debilitating that patients seek emergent treatment. As several neurologic emergencies can present with headaches and focal neurologic findings, it is critical to rule out these conditions as possible etiologies. Once life-threatening emergencies have been ruled out, these headaches can be debilitating enough to require emergency department or inpatient hospital management. We propose an inpatient course of intravenous medications to reduce headache in this population.